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Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design |
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| Authors: | Bonsignori Mattia Montefiori David C Wu Xueling Chen Xi Hwang Kwan-Ki Tsao Chun-Yen Kozink Daniel M Parks Robert J Tomaras Georgia D Crump John A Kapiga Saidi H Sam Noel E Kwong Peter D Kepler Thomas B Liao Hua-Xin Mascola John R Haynes Barton F |
| Institution: | Duke Human Vaccine Institute, Durham, North Carolina, USA. mattia.bonsignori@duke.edu |
| Abstract: | Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities. |
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