Characterization,developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae |
| |
| Authors: | Simona Candiani Mario Pestarino Elena Cattaneo Marzia Tartari |
| |
| Affiliation: | (1) Department of Biology, University of Genoa, viale Benedetto XV 5, 16132 Genoa, Italy;(2) Centre for Stem Cell Research and Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy |
| |
| Abstract: | Background Huntington's disease is an inherited neurodegenerative disorder that is caused by the expansion of an N-terminal polyQ stretch in the huntingtin protein. In order to investigate the hypothesis that huntingtin was already involved in development of the nervous system in the last common ancestor of chordates, we isolated and characterised the huntingtin homologue from the amphioxus Branchiostoma floridae. In the present paper the amphioxus general term must be referred to Branchiostoma floridae. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
