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Distinguishing importation from diversification of quinolone-resistant <Emphasis Type="Italic">Neisseria gonorrhoeae</Emphasis> by molecular evolutionary analysis |
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| Authors: | Marcos Pérez-Losada Keith A Crandall Margaret C Bash Michael Dan Jonathan Zenilman Raphael P Viscidi |
| Institution: | (1) Department of Integrative Biology, Brigham Young University, Provo, UT, USA;(2) Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, USA;(3) Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD, USA;(4) Infectious Diseases Unit, Edith Wolfson Hospital, Tel Aviv, Israel;(5) Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore MD, USA;(6) Stanley Division, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore MD, USA |
| Abstract: | BackgroundDistinguishing the recent introduction of quinolone resistant gonococci into a population from diversification of resistant strains already in the population is important for planning effective infection control strategies. We applied molecular evolutionary analyses to DNA sequences from 9 housekeeping genes and gyrA, parC and porB of 24 quinolone resistant N. gonorrhoeae (QRNG) and 24 quinolone sensitive isolates collected in Israel during 2000–2001. |
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