| 抗菌i－RNA没有传递特异性体液免疫活性能力的确定及其对机体免疫功能影响的研究 |
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| 引用本文： | 曲阳,叶小卉,杨晓临.抗菌i－RNA没有传递特异性体液免疫活性能力的确定及其对机体免疫功能影响的研究[J].微生物学杂志,1996(4). |
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| 作者姓名： | 曲阳 叶小卉 杨晓临 |
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| 作者单位： | 中国医科大学微生物教研室 |
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| 摘 要： | 本实验用抗绿脓杆菌ｉ－ＲＮＡ致敏小鼠，用酶联免疫吸附试验直接检测鼠体内绿脓杆菌特异性抗体的产生，并通过电镜技术观察补体参与下的溶菌杀菌现象来间接反映体内是否有特异性抗体的产生。结果证实ｉ－ＲＮＡ没有传递特异性体液兔疫活性的能力。但小鼠体内脾细胞抗体产生能力，巨噬细胞吞噬活性，脾细胞ＮＫ活性和ＩＬ－２活性均明显高于正常鼠，提示抗菌ｉ－ＲＮＡ有佐剂活性，可以增强机体的体液免疫功能和细胞免疫功能。
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| 关 键 词： | 免疫核糖核酸 抗体产生 免疫功能 |
STUDY ON TRANSFER OF HUMORAL IMMUNAL ACTIVITY BY I-RNA AND ITS EFFECT ON BODY IMMUNITY |
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| Qn Yang et al..STUDY ON TRANSFER OF HUMORAL IMMUNAL ACTIVITY BY I-RNA AND ITS EFFECT ON BODY IMMUNITY[J].Journal of Microbiology,1996(4). |
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| Authors: | Qn Yang |
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| Abstract: | Serum antibody were determined by ELISA. immunoelectromicroscopytechnique in mice immunized with Pa-iRNA. It was shown that corresponding serum antibodies were not found in Pa-iRNA-immunized group.However. it was. demonstrated that antibody productivity, engulfmentactivity of macroghages, NK activity of spleen cells and IL-2 activityin iRNA-immunized groups were all significantly higher than that innormal group. So it can be proyed that Pa-iRNA has adjuvant activity,and it can enhance humoral immunity of the organism and immunity ofthe cells. |
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| Keywords: | I-RNA:Antibody production:Immunity |
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