| 非典型应答调控蛋白活性调控机制 |
| |
| 引用本文： | 彭晓静,季俊杰,张玉秀,杨克迁,张红梅,朱卉. 非典型应答调控蛋白活性调控机制[J]. 生物工程学报, 2012, 28(5): 531-539 |
| |
| 作者姓名： | 彭晓静 季俊杰 张玉秀 杨克迁 张红梅 朱卉 |
| |
| 作者单位： | 中国矿业大学 (北京) 化学与环境工程学院，北京 100083;中国矿业大学 (北京) 化学与环境工程学院，北京 100083;中国矿业大学 (北京) 化学与环境工程学院，北京 100083;中国科学院微生物研究所 微生物资源前期开发国家重点实验室，北京 100101;中国矿业大学 (北京) 化学与环境工程学院，北京 100083;中国矿业大学 (北京) 化学与环境工程学院，北京 100083 |
| |
| 基金项目： | 国家转基因生物新品种培育重大专项 (No. 2009ZX08009-130B)，中国矿业大学（北京）大学生创新性实验计划”项目 (No. 110309z)，中央高校基本科研业务费项目 (No. 2012YH05) 资助。 |
| |
| 摘 要： | 双组分信号转导系统是生物中广泛存在的调控系统,通常由组氨酸激酶和应答调控蛋白(Responseregulator,RR)两个组分构成。典型的RR通过一个磷酸化机制调控活性。非典型应答调控蛋白在细菌中广泛存在,并调控细菌的生长发育、抗生素合成、Fe的转运等多种生理功能。以下主要综述目前研究比较清楚的非典型应答调控蛋白的结构和功能方面的进展,并以链霉菌中杰多霉素生物合成途径中的非典型应答调控蛋白JadR1为例,阐明调控蛋白活性调控的新机制。
|
| 关 键 词： | 非典型应答调控蛋白 JadR1 杰多霉素 |
| 收稿时间： | 2011-11-25 |
Progress in the understanding of the function of atypical response regulators: a review |
| |
| Xiaojing Peng,Junjie Ji,Yuxiu Zhang,Keqian Yang,Hongmei Zhang and Hui Zhu. Progress in the understanding of the function of atypical response regulators: a review[J]. Chinese journal of biotechnology, 2012, 28(5): 531-539 |
| |
| Authors: | Xiaojing Peng Junjie Ji Yuxiu Zhang Keqian Yang Hongmei Zhang Hui Zhu |
| |
| Affiliation: | School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China;;School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China;;School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China;;State key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China;;School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China; |
| |
| Abstract: | Two component system is a signal transduction system. It typically consists of a sensor histitine kinase and a cognate response regulator (RR) component. The activity of RR is regulated by a phosphorylation dependent mechanism. In recent years, the existence of atypical response regulators (ARRs), which rely on a phosphorylation independent mechanism to regulate their activity, have been recognized. ARRs are involved in the regulation of bacterial growth and development, antibiotic biosynthesis, iron transport, among others. Here we review the recent advances in the understanding of the structure and function of atypical response regulators, by using JadR1, a regulator in jadomycin biosynthesis in Streptomyces, as an example to elucidate the novel mechanism used by ARR to fine-tune its activity. |
| |
| Keywords: | atypical response regulator JadR1 jadomycin |
| 本文献已被 CNKI PubMed 等数据库收录！ |
| 点击此处可从《生物工程学报》浏览原始摘要信息 |
|
点击此处可从《生物工程学报》下载全文 |
|
