Detection of four human milk groups with respect to Lewis blood group dependent oligosaccharides |
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Authors: | Stephan Thurl Jobst Henker Manfred Siegel Karlheinz Tovar Gunther Sawatzki |
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Institution: | (1) Research Department, Milupa GmbH & Co. KG, 61381 Friedrichsdorf, Germany;(2) Technische Universitat Dresden, Universitatsklinikum Carl Gustav Carus, 01307 Dresden, Germany;(3) DRK Blutspendedienst Sachsen, Institute of Transfusion Medicine, 01307 Dresden, Germany |
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Abstract: | Neutral oligosaccharides in human milk samples from approximately 50 women were analysed applying a recently developed high-pH
anion-exchange chromatographic method. Three different oligosaccharide patterns could be detected in accordance with milk
groups that had been already described. These oligosaccharide groups correspond to the Lewis blood types Le(a−b+), Le(a+b−)
and Le(a−b−). In addition to these oligosaccharide patterns, a new carbohydrate pattern was detected in a milk sample from
a Le(a−b−) individual. Here, only nonfucosylated oligosaccharides and compounds bearing a1,3 linked fucosyl residues were found, whereas structures with a1,2 and a1,4 fucosyl linkages were missing. This finding led to the hypothesis that there are four different oligosaccharide milk groups
that fit well to the genetic basis of the Lewis blood group system.
This revised version was published online in November 2006 with corrections to the Cover Date. |
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Keywords: | human milk oligosaccharide pattern Lewis blood group |
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