Role of persisting opportunistic bacteria in the pathogenesis of the gastric and duodenum ulcer

Dynamic study of the bacterial microflora of 122 patients with gastric and duodenal ulcer was carried out. Microflora examination of the bioptic samples of mucosa, obtained from the ulcerous zone of the patients, revealed that an open ulcer is like an infected wound needing sanitation. In the focus of lesion microorganisms of 32 genera and species, including Helicobacter pylori, fungi of the genus Candida, representatives of the genera Streptococcus, Staphylococcus, Corynebacterium, Bacteroides, etc., were detected. Opportunistic microorganisms were isolated in associations (up to 8 different cultures), possessing cytotoxic, hemolytic, antilysozyme, lecithinase, caseinolytic and RNAase activities. To inhibit the microflora, chitosan was used; 82-85% of the cultures of different bacteria under study proved to be sensitive to it. The inclusion of chitosan into the complex therapy suppressed the persistence of H. pylori, ensured the sanitation of mucosa affected by opportunistic bacteria and accelerated ulcers cicatrization.