Analysis of the association between the T113M polymorphism of the human il-9 gene and bronchial asthma |
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Authors: | Fre?din M B Puzyrev V P Ogorodova L M Saliukova O A Kamaltynova E M Kulmanakova I M Petrovskaia Iu A |
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Institution: | Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Russia. |
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Abstract: | The T113M polymorphism resulting from the missense mutation in exon 5 of the human interleukin 9 (IL9) gene was tested for association with bronchial asthma (BA). The genotype frequency analysis did not reveal a deviation from the Hardy-Weinberg equilibrium. A comparison of the genotype frequency distributions in a control group of healthy individuals and in patients with BA suggested an association between T113M and the clinical phenotype. However, this association was not confirmed by the affected family-based association control (AFBAC) or the transmission/disequilibrium test (TDT). |
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