Periplasmic superoxide dismutase from Desulfovibrio desulfuricans 1388 is an iron protein |
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| Authors: | M N Davydova O V Gorshkov N B Tarasova |
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| Institution: | (1) Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Sciences, ul. Lobachevskogo 2/31, 420111 Kazan, Russia |
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| Abstract: | It is shown that the genome of the sulfate-reducing bacterium Desulfovibrio desulfuricans 1388 contains a superoxide dismutase (SOD) gene (sod). The gene encodes an export signal peptide characteristic for periplasmic redox proteins. The amino acid sequence showed high homology with iron-containing SODs from other bacteria. Electrophoretically pure SOD was isolated from the periplasmic fraction of bacterial cells by FPLC chromatography. Like other Fe-SODs, D. desulfuricans 1388 superoxide dismutase is inhibited by H2O2 and azide, but not by cyanide. |
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| Keywords: | sulfate-reducing bacteria Desulfovibrio desulfuricans Fe-SOD |
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