Biotransformation of three pharmaceutical active compounds by the fungus Phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply |
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Authors: | A I Rodarte-Morales G Feijoo M T Moreira J M Lema |
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Institution: | (1) Department of Chemical Engineering, School of Engineering, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain |
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Abstract: | White-rot fungi are a group of microorganisms capable of degrading xenobiotic compounds, such as polycyclic aromatic hydrocarbons
or synthetic dyes, by means of the action of extracellular oxidative enzymes secreted during secondary metabolism. In this
study, the transformation of three anti-inflammatory drugs: diclofenac, ibuprofen and naproxen were carried out by pellets
of Phanerochaete chrysosporium in fed-batch bioreactors operating under continuous air supply or periodic pulsation of oxygen. The performance of the fungal
reactors was steady over a 30-day treatment and the effect of oxygen pulses on the pellet morphology was evidenced. Complete
elimination of diclofenac was achieved in the aerated and the oxygenated reactors, even with a fast oxidation rate in the
presence of oxygen (77% after 2 h), reaching a total removal after 23 h. In the case of ibuprofen, this compound was completely
oxidized under air and oxygen supply. Finally, naproxen was oxidized in the range of 77 up to 99% under both aeration conditions.
These findings demonstrate that the oxidative capability of this microorganism for the anti-inflammatory drugs is not restricted
to an oxygen environment, as generally accepted, since the fungal reactor was able to remove these compounds under aerated
and oxygenated conditions. This result is very interesting in terms of developing viable reactors for the oxidation of target
compounds as the cost of aeration can be significantly reduced. |
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