Guggulsterone enhances glycosylated low density lipoprotein binding in rat liver |
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Authors: | Vinita Singh Narinder K Kapoor |
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Institution: | (1) Division of Biochemistry, Central Drug Research Institute, 226 001 Lucknow, India |
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Abstract: | Modification of low density lipoprotein by nonenzymic glycosylation resulted in decreased receptor-mediated lipoprotein catabolism.
Guggulsterone treatment caused significant increase in binding of 125I] low density lipoprotein as well as 125I] glycosylated low density lipoprotein. Scatchard plot analysis of the binding activity revealed that under the influence
of guggulsterone, the liver membrane contains increased amounts of a functional lipoprotein receptor that binds more low density
lipoprotein particles. |
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Keywords: | Guggulsterone glycosylation liver membrane low density lipoprotein binding |
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