WWOX蛋白在胰腺癌组织中的表达及其临床意义

目的探讨WWOX蛋白在胰腺癌组织中的表达及其临床意义。方法应用免疫组织化学孓P法检测人胰腺癌组织芯片150芯（包括70例胰腺癌组织和5例胰腺炎）中WWOX蛋白的表达，采用HPIAS-1000图文报告管理系统对WWOX蛋白的表达进行定量分析，并用SPSS11．5软件对各组免疫组织化学反应阳性颗粒的平均光密度、阳性面积率做单因素方差分析和SNK（q）检验。结果胰腺癌组织中WWOX蛋白呈低表达，胰腺炎组织中WWOX蛋白呈高表达。结论提示WWOX基因表达下调可能在胰腺癌的发生、发展中起了重要作用。

Expression and clinical significance of WWOX protein in human pancreatic cancinoma tissues by tissue microarray

Objective To detect the expression and clinical significance of WWOX proteins in human Pancreatic cancinoma tissues and pancreatitis tissues. Methods We examined the expression of WWOX pro- teins in human Pancreatic cancinoma and pancreatitis tissues with microarray of 150 chips （70 cases of pan- creatic carcinoma and 5 of pancreatitis） by using immunohistochemical technique, The results of immuno- histochemical dyeing were analyzed by multi-spectral imaging systems to perform quantitative analysis of WWOX protein. Analysis of variance （ANOVA） and SNK（q） test were used with SPSS13.0 to analyze the data from quantum dot dyeing（a=0.05）. Results The expression of WWOX proteins was low in hu- man pancreatic cancinoma tissues, but high expression in pancreatitis tissues. The difference was statisti- cally significant （P〈 0.05）. Conclusion The down-regulatio of WWOX gene expression may play an im- portant role the occurrence and development of pancreatic cancinoma .