Mutagenicity of 22 N-nitrosamides and related compounds for Salmonella typhimurium TA1535. |
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Authors: | K Lee B Gold S S Mirvish |
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Institution: | Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68105, U.S.A. |
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Abstract: | Twenty-two N-nitrosamides and related compounds, including 14 nitrosoureas, 5 nitrosocarbamates, and one nitrosocyanamide, were tested at various concentrations for mutagenic activity towards Salmonella typhimurium TA1535 without the use of microsomes. The ether-water partition coefficient, solubility in water, and half-life in aqueous solution were also measured. Twenty compounds were mutagenic, with "standard mutagenic concentrations" (i.e. those producing 100 mutants/dish) of 0.0024--6500 micron. Standard mutagenic concentration was negatively correlated with the partition coefficient. Three compounds (ethyl 2-acetoxyethylnitrosocarbamate, nitrosocarbaryl, and methylnitrosobenzamide) were more active than the classic mutagen methylnitrosonitroguanidine. Nitrosocarbamates were at least 50 times more mutagenic than the corresponding nitrosoureas. Nitrosodihydrouracil and propylene-nitrosourea were more active than related compounds. Ethylnitrosocyanamide was 730 times more mutagenic than ethylnitrosourea. Fifteen of the test compounds (of which 14 were mutagenic) had previously been assayed in rats for carcinogenicity, all with positive results. |
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Keywords: | AAF 2-acetyl aminofluorene 8AmQ 8-aminoquinoline Ar Aroclor 1254 (injection)-induced rat liver microsomal preparation (S-9) BP benzo(a)pyrene EMS ethyl methanesulfonate HC hycanthone MMS methyl methanesulfonate φB phenobarbital (in drinking water)-induced rat liver microsomal preparation (S-9) Ui uninduced (control) rat liver microsomal preparation (S-9) |
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