Protein folding by 'levels of separation': a hypothesis |
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Authors: | Greene Lesley H Grant Terri M |
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Institution: | Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA 23529, USA. |
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Abstract: | The protein folding process has been studied both computationally and experimentally for over 30 years. To date there is no detailed mechanism to explain the formation of long-range interactions between the transition and native states. Long-range interactions are the principle determinants of the tertiary structure. We present a theoretical model which proposes a mechanism for the acquisition of these interactions as they form in a modified version of 'degrees of separation', that we term 'levels of separation'. It is based on the integration of network science and biochemistry. |
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