Effects of thyroid hormone on mRNAs of phosphoglycerate mutase subunits in rat muscle during development |
| |
Authors: | González-Cinca Núria Gonzalo Sergio Ascaso Carlos Carreras José Climent Fernando |
| |
Affiliation: | Unitat de Bioquimica, Departament de Ciéncies Fisiològiques I, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina, Universitat de Barcelona, Spain. |
| |
Abstract: | BACKGROUND: We previously showed that triiodothyronine (T3) stimulates muscle phosphoglycerate mutase (PGAM) activity and isozyme transition in rat skeletal and cardiac muscles. METHODS: The effects of T3 on PGAM types B and M subunit expression in rat muscle during development are reported. RESULTS: T3 administration during the first 21 days of rat life more than doubles type M PGAM mRNA levels, but produces minor effects on type B PGAM mRNA levels. The antihormone propylthiouracil (PTU) slightly decreases both type B and M mRNA levels, but this decrease is not statistically significant. CONCLUSION: Thyroid hormone influences PGAM mRNA isozyme levels differently and increases type M mRNA. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|