| 甾醇侧链切除的微生物转化技术 |
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| 引用本文： | 王志龙.甾醇侧链切除的微生物转化技术[J].工业微生物,2006,36(3):49-54. |
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| 作者姓名： | 王志龙 |
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| 作者单位： | 上海交通大学药学院,上海,200240 |
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| 摘 要： | 甾体化合物是医药工业中具有巨大市场的产品之一,甾醇侧链切除的微生物转化是解决甾体医药原料的基础,像甾醇这一类疏水性底物的微生物转化技术是产业化的关键。本文综述了甾醇侧链切除微生物转化技术的新进展,详细介绍了我们最近开发的浊点系统两相分配生物反应器新技术。
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| 关 键 词： | 甾醇 侧链切除 微生物转化 浊点系统 两相分配生物反应器 |
Sterol side-chain cleavage by microbial transformation |
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| WANG Zhi-long.Sterol side-chain cleavage by microbial transformation[J].Industrial Microbiology,2006,36(3):49-54. |
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| Authors: | WANG Zhi-long |
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| Institution: | School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Abstract: | Steroid compounds are some kinds of the pharmaceutical products with great commercial value.Sterol side-chain cleavage by microbial transformation provides its potential raw materials.However,the industry process is constrained by its microbial transformation technique due to the hydrophobicity of sterols.The development of microbial transformation technique for sterol side-chain cleavage is reviewed.Furthermore,the cloud point system and a novel two-phase partitioning bioreactor exploited recently for microbial transformation of hydrophobic compounds is also introduced. |
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| Keywords: | sterol side-chain cleavage microbial transformation cloud point system two-phase partitioning bioreactor |
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