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Characterization of the human immune response to the UK anthrax vaccine
Authors:Baillie Les  Townend Tim  Walker Nicki  Eriksson Ulla  Williamson Diane
Institution:Biodefense Vaccines, Biological Defense Research Directorate, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA. bailliel@mmrc.navy.mil
Abstract:The anthrax bipartite lethal toxin (protective antigen (PA) and lethal factor (LF))-specific antibody responses of humans receiving the UK licensed anthrax vaccine were determined. The PA-specific IgG response peaked two weeks post immunization and fell back to pre-boost levels by week 12. The heterogeneity of the host population modulated the extent of the PA-specific antibody response. Significantly lower levels of LF-specific antibodies were also detected. Vaccinated individuals recognized the same PA epitope as the protective mouse lethal toxin neutralizing monoclonal 2D3 suggesting that this may also be a target for human protection.
Keywords:Anthrax vaccine  Lethal toxin  Immune responses  Epitopes
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