Characterization of the human immune response to the UK anthrax vaccine |
| |
Authors: | Baillie Les Townend Tim Walker Nicki Eriksson Ulla Williamson Diane |
| |
Institution: | Biodefense Vaccines, Biological Defense Research Directorate, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA. bailliel@mmrc.navy.mil |
| |
Abstract: | The anthrax bipartite lethal toxin (protective antigen (PA) and lethal factor (LF))-specific antibody responses of humans receiving the UK licensed anthrax vaccine were determined. The PA-specific IgG response peaked two weeks post immunization and fell back to pre-boost levels by week 12. The heterogeneity of the host population modulated the extent of the PA-specific antibody response. Significantly lower levels of LF-specific antibodies were also detected. Vaccinated individuals recognized the same PA epitope as the protective mouse lethal toxin neutralizing monoclonal 2D3 suggesting that this may also be a target for human protection. |
| |
Keywords: | Anthrax vaccine Lethal toxin Immune responses Epitopes |
本文献已被 PubMed 等数据库收录! |