H1-histaminergic activation stimulates inositol-1-phosphate accumulation in chromaffin cells |
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| Authors: | E P Noble M Bommer E Sincini T Costa A Herz |
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| Institution: | 1. Alcohol Research Center, The Neuropsychiatric Institute, University of California, Los Angeles, CA 90024 USA;2. Brain Research Institute, University of California, Los Angeles, CA 90024 USA;3. the Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie D-8033 Planegg-Martinsried, Federal Republic of Germany;1. Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi׳an 710032, China;2. Department of Neurology, Shaanxi Provincial People׳s Hospital, Xi׳an 710068, China;3. Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, China;1. DOS in Biochemistry, University of Mysore, Manasagangothri, Mysuru 570 006, India;2. Department of Studies and Research in Biochemistry, Tumkur University, Tumakuru 572 103, India |
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| Abstract: | Adrenal medullary chromaffin cells maintained in vitro were prelabeled with 3H]inositol and the accumulation of 3H]inositol-1-phosphate, was determined following stimulation with a variety of pharmacological agents. Carbachol, bradykinin, and histamine produced significantly greater accumulation of 3H] inositol-1-phosphate over basal levels, with histamine producing the greatest effect. H1-histamine receptor antagonists, mepyramine, pyrilamine, tripelennamine and clemastine were all able to reduce or completely block the histamine response. The two specific H2-histamine receptor antagonists, cimetidine and ranitidine, had no effect on this response. Histamine dose-response characteristics in the presence of mepyramine and clemastine suggest the H1 antagonism to be competitive in nature. |
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