| 基于代谢组学的抗生素与细菌间作用研究进展 |
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| 引用本文： | 陈敏玲,韦献虎,张菊梅,丁郁,吴清平.基于代谢组学的抗生素与细菌间作用研究进展[J].微生物学报,2022,62(2):403-413. |
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| 作者姓名： | 陈敏玲 韦献虎 张菊梅 丁郁 吴清平 |
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| 作者单位： | 广东省科学院微生物研究所, 华南应用微生物国家重点实验室, 广东省微生物安全与健康重点实验室, 广东 广州 510070;华南理工大学生物科学与工程学院, 广东 广州 510006 |
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| 基金项目： | 国家自然科学基金（31730070）；广东省“珠江人才计划”本土创新团队（2017BT01S174）；广东省科学院项目（2020GDASYL-20200401002）；广东省重点实验室（2020B121201009） |
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| 摘 要： | 抗生素杀菌是一个复杂的生理过程,杀菌抗生素与靶点作用后的下游代谢变化与抗生素作用效果紧密联系,其通过干扰细菌代谢状态加速死亡进程,而细菌改变代谢状态也能影响抗生素的有效性.代谢组学通过监测细菌在抗生素作用下的变化提供全面代谢信息,我们回顾近年来基于代谢组学对抗生素与细菌间作用的研究进展,以期为开发抗生素佐剂提高抗生素效...
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| 关 键 词： | 代谢组学 细菌代谢 细菌耐药 抗生素佐剂 |
| 收稿时间： | 2021/3/29 0:00:00 |
| 修稿时间： | 2021/6/1 0:00:00 |
Research progress of the interaction between antibiotics and bacteria based on metabolomics |
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| CHEN Minling,WEI Xianhu,ZHANG Jumei,DING Yu,WU Qingping.Research progress of the interaction between antibiotics and bacteria based on metabolomics[J].Acta Microbiologica Sinica,2022,62(2):403-413. |
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| Authors: | CHEN Minling WEI Xianhu ZHANG Jumei DING Yu WU Qingping |
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| Institution: | Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China;College of Biological Sciences and Engineering, South China University of Technology, Guangzhou 510006, Guangdong, China |
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| Abstract: | Antibiotic killing is a complex physiological process. The downstream metabolic changes of antibiotic-target interactions are closely related to antibiotic efficacy. Bactericidal antibiotics speed up the death process by perturbing the bacterial metabolism, which also influences the antibiotic efficacy. Metabolomics provides comprehensive metabolic information for monitoring the changes of bacterial metabolism under the action of antibiotics. Here we review recent metabolomics-driven studies on the interaction between antibiotics and bacteria, intending to provide a reference for the development of antibiotic adjuvants to enhance the antibiotic efficacy. |
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| Keywords: | metabolomics bacterial metabolism bacterial resistance antibiotic adjuvants |
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