New developments in the antifungal susceptibility testing of Candida |
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Authors: | Michael A Pfaller |
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Institution: | (1) Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA;(2) Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA |
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Abstract: | Antifungal susceptibility testing of Candida spp has been standardized and refined and now may play an important role in managing Candida infections. Important new developments include standardizing methods for testing echinocandins, fluconazole, and voriconazole
and establishing interpretive breakpoints for these agents. Refinements in broth microdilution technology include the ability
to read results after 24-hour incubation for several agents, addition of new azoles and echinocandins to commercially available
microdilution trays, and automation of the entire testing process. Cross-resistance studies have identified important relationships
among the triazole antifungals, and international collaboration offers the promise of harmonization and the development of
an international standard for the testing of yeasts. |
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