Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain |
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| Authors: | Siddiqui Nadeem Pandeya Surendra N Khan Suroor A Stables James Rana Arpana Alam Mahfuz Arshad Md Faiz Bhat Mashooq A |
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| Institution: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110 062, India. nadeems_03@yahoo.co.in |
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| Abstract: | A series of sulphonamide derivatives (1-11) were synthesized in good yield and evaluated for their possible anticonvulsant activity and neurotoxic study. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in MES and scPTZ tests. All the compounds were less toxic than the standard drug phenytoin. |
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