Isolation and Characterization of a New T-Even Bacteriophage, CEV1, and Determination of Its Potential To Reduce Escherichia coli O157:H7 Levels in Sheep |
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| Authors: | Raul R. Raya Peter Varey Rebecca A. Oot Michael R. Dyen Todd R. Callaway Tom S. Edrington Elizabeth M. Kutter Andrew D. Brabban |
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| Abstract: | Bacteriophage CEV1 was isolated from sheep resistant to Escherichia coli O157:H7 colonization. In vitro, CEV1 efficiently infected E. coli O157:H7 grown both aerobically and anaerobically. In vivo, sheep receiving a single oral dose of CEV1 showed a 2-log-unit reduction in intestinal E. coli O157:H7 levels within 2 days compared to levels in the controls. |
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