EPITHELIAL COLLAGENS AND GLYCOSAMINOGLYCANS IN THE EMBRYONIC CORNEA : Macromolecular Order and Morphogenesis in the Basement Membrane |
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Authors: | Robert L Trelstad Kimiko Hayashi and Bryan P Toole |
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Institution: | From the Developmental Biology Laboratory, Departments of Medicine and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 |
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Abstract: | The embryonic corneal epithelium synthesizes both collagen and chondroitin sulfate and excretes them across the basement membrane into the subepithelial space where they assemble into a spiraling orthogonal matrix of fibrils. The assembly of collagen into fibrils is first apparent at the outer face of the basement membrane in a region of ordered chondroitin sulfate molecules. Hyaluronate, another morphogenetically important corneal macromolecule, is produced at these early stages only by the inner endothelium. These correlated biosynthetic and ultrastructural data demonstrate discrete macromolecular products of the two corneal epithelia with differing morphogenetic properties and functions. |
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