Synthesis of novel difluoro-cyclopropyl guanine nucleosides and their phosphonate analogues as potent antiviral agents |
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| Authors: | Li Hua Yoo Jin Cheol Kim Eunae Hong Joon Hee |
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| Institution: | BK-21 Project Team, College of Pharmacy, Chosun University, Kwangju, Republic of Korea. |
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| Abstract: | The synthesis of new rigid guanine analogues with anti-HIV-1 and anti-herpes viral activities is described. The phosphonate of difluorocyclopropane nucleoside analogue 26 exhibits in vitro anti-HIV-1 activity similar to that of PMEA in MT-4 cells. Further, analogue 20 shows moderate anti-HCMV activity in MRC cells. |
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