Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A |
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| Authors: | Hong Joon Hee Kim So-Young Oh Chang-Hyun Yoo Kyung Ho Cho Jung-Hyuck |
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| Institution: | Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Korea. |
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| Abstract: | Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds Ia-II were evaluated for their antiviral activity against various viruses such as HIV HSV-1, HSV-2, and ECMV. |
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