Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon |
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Authors: | Sofia Consuegra Ian A Johnston |
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Institution: | (1) Fish Muscle Research Group, Gatty Marine Laboratory, School of Biology, University of St Andrews, St Andrews, Fife, KY16 8LB, UK;(2) Swansea University, Biological Sciences, Institute of Environmental Sustainability, Singleton Park, Swansea, SA2 8PP, UK |
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Abstract: | We examined the polymorphism of the lysyl oxidase (LOX) locus, involved in the initiation of muscle collagen cross-linking, in three populations of Atlantic salmon with different
life histories and growth rates and compared it with a closely related species (rainbow trout). Up to four alleles were observed
per individual, probably as a consequence of the tetraploid origin of the salmonid genome. We found high polymorphism in the
LOX locus (16 alleles expressed in total and several low frequency private alleles) in two natural Atlantic salmon populations
and extremely reduced diversity in a farmed population (3 alleles) with low density of collagen crosslinks. We also assessed
the relative role of selection in maintaining LOX genetic variability in Atlantic salmon. Results from several neutrality tests suggest that selection is playing a role in
shaping diversity at the LOX locus. Positive selection was inferred by three different likelihood phylogeny-based methods and one selected site, identified
by all three different methods (PAML, FEL and REL) was located within the “copper-talon” characteristic of LOX proteins. We
suggest that the retention of four alleles in the salmon LOX locus could be related to its multiple functions. |
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Keywords: | Adaptive evolution Collagen cross-links Lysyl oxidase Positive selection Salmo salar |
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