Resistance to oxidative stress in a freshwater fish Channa punctatus after exposure to inorganic arsenic |
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Authors: | Tanu Allen Ritu Singhal S V S Rana |
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Institution: | (1) Department of Environmental Science, Ch. Charan Singh University, 250004 Meerut, India;(2) Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, 250004 Meerut, India |
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Abstract: | The biochemical toxicity of arsenic trioxide (AsIII) in a freshwater edible fish Channa punctatus has been studied on exposures ranging from 7 to 90 d. The arsenic concentration increased exponentially in liver, kidney,
gills, and muscles of fish up to 60 d of exposure to arsenic. However, arsenic concentration in these tissues declined at
90 d of exposure. This relationship between period of exposure and concentration of arsenic in selected tissues suggests an
adaptive response of fish to arsenic. Furthermore, exposure to arsenic-induced lipid peroxidation in these organs increased
initially at 7 d of exposure; however, it decreased up to 60 d of exposure but increased again at 90 d of treatment. Values
of reduced glutathione (GSH) reflected the observations of lipid peroxidation. The role of GSH in this adaptive response has
been discussed. |
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Keywords: | Arsenic trioxide fish liver kidney gills GSH lipid peroxidation |
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