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Identification of purine inhibitors of phosphodiesterase 7 (PDE7) |
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| Authors: | Pitts William J Vaccaro Wayne Huynh Tram Leftheris Katerina Roberge Jacques Y Barbosa Joseph Guo Junqing Brown Baerbel Watson Andrew Donaldson Karen Starling Gary C Kiener Peter A Poss Michael A Dodd John H Barrish Joel C |
| Affiliation: | Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. pittsw@bms.com |
| Abstract: | A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described. |
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