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Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM |
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| Authors: | Makoto Daimon Toshihide Oizumi Shigeru Karasawa Kiriko Wada Shinji Susa Isao Kubota Takeo Kato |
| Affiliation: | a Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan b 21st Century Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan c HuBit Genomix Research Institute, Tokyo, Japan d Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan |
| Abstract: | The association of the Ser326Cys polymorphism of the 8-oxoguanine glycosylase 1 (OGG1) gene with type 2 diabetes was examined using a Japanese population (n (M/W): 4585 (2085/2500); age: 62.6 ± 10.9 years). HbA1c levels and frequency of diabetic subjects were significantly higher in subjects with genotypes with Cys allele than in those without (p = 0.032 and 0.037, respectively). Multiple logistic regression analysis showed that genotypes with Cys allele were significantly associated with diabetes (OR: 1.32, p = 0.0289). In subjects whose glucose tolerance was classified by FPG and 2-h PG (n = 1.634), the association was more substantial (genotypes with Cys allele vs. without, OR: 1.70, p = 0.0059; genotypes Cys/Cys vs. Ser/Ser, OR: 2.19, p = 0.0008). In subjects with genotype Ser/Ser, the insulin secretion index, HOMA-β, increased in the subjects with glucose intolerance and decreased in the subjects with diabetes, while, in subjects with genotypes Ser/Cys + Cys/Cys, HOMA-β decreased as the glucose tolerance progressed (p for trend = 0.010). |
| Keywords: | DNA damage Population-based study Takahata study Funagata study 8-Oxoguanine glycosylase 1 β-Cell function |
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