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Natural conditions inducing programmed cell death in the yeast Saccharomyces cerevisiae
Authors:D.?A.?Knorre,E.?A.?Smirnova,F.?F.?Severin  author-information"  >  author-information__contact u-icon-before"  >  mailto:severin@mpi-cbg.de"   title="  severin@mpi-cbg.de"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:(1) Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia;(2) BioTechnological Center, University of Technology Dresden, Tatzberg 49, D-01307 Dresden, Germany
Abstract:Although yeasts have been extensively used as an experimental model to study apoptosis, it is still unclear why a unicellular organism like yeast possesses a suicide program. Here we discuss three hypothetical scenarios of ldquo naturalrdquo yeast suicide. We argue that by correctly deducing the physiological situation(s) for yeast to undergo cell death, one can not only improve the efficiency of yeast as model system for apoptotic studies, but also obtain a certain insight into the survival strategies of communities of organisms.Translated from Biokhimiya, Vol. 70, No. 2, 2005, pp. 323–326.Original Russian Text Copyright © 2005 by Knorre, Smirnova, Severin.This revised version was published online in April 2005 with corrections to the post codes.
Keywords:yeast  programmed cell death  mitochondria  membrane potential  pheromone  reactive oxygen species (ROS)  sporulation
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