Membrane lipid peroxidation by ultrasound: Mechanism and implications |
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Authors: | A K Jana S Agarwal S N Chatterjee |
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Institution: | (1) Biophysics Division, Saha Institute of Nuclear Physics, 37 Belgachia Road, 700 037 Calcutta, India |
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Abstract: | Ultrasonic radiation produced a dose-dependent linear increase in lipid peroxidation in the liposomes membrane as reflected
in the measurement of conjugated dienes, lipid hydroperoxides and malondialdehydes. Ultrasound induced malondialdehyde production
could not be inhibited by any significant degree by superoxide dismutase or histidine or dimethyl furan but was very significantly
inhibited by butylated hydroxytoluene, cholesterol, sodium benzoate, dimethyl sulphoxide, sodium formate and EDTA. The scavenger
studies indicated the functional role of hydroxyl radicals in the initiation of ultrasound induced lipid peroxidation. |
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Keywords: | Ultrasound liposomes lipid peroxidation hydroxyl radicals scavengers |
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