Increased potency of a novel d-β-naphthylalanine-substituted antimicrobial peptide against fluconazole-resistant fungal pathogens |
| |
| Authors: | Chih-Wei Wang,Bak-Sau Yip,His-Tsung Cheng,An-Huei Wang,Heng-Li Chen,Jya-Wei Cheng,& Hsiu-Jung Lo |
| |
| Affiliation: | Division of Infectious Diseases, National Health Research Institutes, Miaoli, Taiwan;and;Department of Life Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan |
| |
| Abstract: | The antifungal activities of the known antimicrobial peptide, P-113, as well as a new type of Trp-rich peptide, Ac-KWRRWVRWI-NH2, Pac-525, and its modified peptide, d -Nal-Pac-525, were determined using the broth microdilution method in three different media. All peptides had similar activities against yeast pathogens in low-salt LYM media. However, only d -Nal-Pac-525 retained its antifungal activity in the media containing high concentrations of salt. Hence, d -Nal-Pac-525 has the potential of becoming a promising antifungal agent, especially for fungal pathogens with intrinsic resistance to fluconazole. |
| |
| Keywords: | antimicrobial peptides fungal pathogens drug resistance |
|
|
