| 内含子在生物信息学研究和基因工程中的应用 |
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| 引用本文： | 陈兵,文建凡.内含子在生物信息学研究和基因工程中的应用[J].生命的化学,2010(1). |
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| 作者姓名： | 陈兵 文建凡 |
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| 作者单位： | 中国科学院昆明动物研究所遗传资源与进化国家重点实验室;中国科学院研究生院; |
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| 基金项目： | 国家基金委项目(30021004,30623007); 科技部“973”项目(2007CB815705)资助 |
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| 摘 要： | 内含子在真核生物基因组中广泛存在。已有的研究虽揭示出内含子对基因的表达有着重要的调节作用,并参与了基因的进化,但内含子的功能还远没有弄清楚,对其本身的起源与演化问题也还存在很大争论。尽管如此,目前内含子在生物信息学研究和基因工程中的应用已蓬勃展开。本文就人们目前对内含子的基因组分析、分子进化与分子系统分析研究以及内含子在转基因工程中的应用作一概述。
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| 关 键 词： | 内含子 基因组分析 进化分析 转基因 |
Application of intron in bioinformatics researches and transgenic engineering |
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| Bing Chen,Jian-Fan Wen State Key Laboratory of Genetic Resources , Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan ,China,Graduate School of the Chinese Academy of Sciences,Beijing.Application of intron in bioinformatics researches and transgenic engineering[J].Chemistry of Life,2010(1). |
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| Authors: | Bing Chen Jian-Fan Wen State Key Laboratory of Genetic Resources Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China Graduate School of the Chinese Academy of Sciences Beijing |
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| Institution: | Bing Chen,Jian-Fan Wen 1State Key Laboratory of Genetic Resources , Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China,2Graduate School of the Chinese Academy of Sciences,Beijing 100039 |
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| Abstract: | Intron is widespread in eukaryotic genomes.It is already known that intron is an important regulation factor of eukaryotic gene expression and is involved in gene evolution.Although the functions of intron are not very clear so far,and its origin and evolution is still a debatable issue,knowledge of intron has been applied in bioinformatic analysis and genetic engineering.In this paper,the application strategies in genomic analysis,molecular evolution and phylogenetic analysis,and transgenic engineering of ... |
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| Keywords: | intron genomic analysis evolutionary analysis transgene |
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