Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart |
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| Institution: | 1. Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building, MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK;2. Development and Cell Biology, University of Southampton School of Biological Sciences, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK;3. Human Genetics Division, University of Southampton School of Medicine, Institute of Developmental Sciences Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK;4. Institute of Developmental Sciences, University of Southampton School of Medicine, Institute of Developmental Sciences Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK |
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| Abstract: | Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100 g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease. |
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