Trace elements content and hormonal profiles in women with androgenetic alopecia |
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| Institution: | 1. Russian Society of Trace Elements in Medicine, Zemlyanoy Val str., 46, Moscow 105064, Russia;2. ANO “Centre for Biotic Medicine”, Zemlyanoy Val str., 46, Moscow 105064, Russia;1. Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA;2. Curriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA;3. Children’s Environmental Health and Disease Prevention Research Center at Dartmouth, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA;4. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA;5. Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA;1. Department of Physiological Sciences, Laboratory of Orofacial Pain, Piracicaba Dental School, University of Campinas – UNICAMP, Av. Limeira, 901, Piracicaba, SP 13414-903, Brazil;2. Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 - Campinas, SP 13045-755, Brazil;1. Division of Cancer Medicine Fellowship Program, University of Texas M.D. Anderson Cancer Center, Houston, TX;2. Essential Health, Essentia Health Duluth Cancer Center, Duluth, MN;3. Diagnostic Radiology Department, University of Texas M.D. Anderson Cancer Center, Houston, TX;4. Biostatistics Department, University of Texas M.D. Anderson Cancer Center, Houston, TX;5. Department of Biostatistics, West Virginia University, Robert C. Byrd Health Sciences Center, Morgantown, WV;6. Genitourinary Medical Oncology Department, University of Texas M.D. Anderson Cancer Center, Houston, TX;1. University of Limerick, Ireland;2. RMIT University, Australia;1. Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China;2. University of Chinese Academy of Sciences, Beijing, China;3. Division of Hematology, Department of Medicine, Baltimore, MD;4. Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD;5. Translational and Functional Genomics Branch, National Institutes of Health, National Human Genome Research Institute, Bethesda, MD |
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| Abstract: | It is well-known that some trace element imbalances play a significant role in the pathomechanism of many forms of alopecia. Androgenetic alopecia, however, is a specific local sensitivity of hair follicle receptors to androgens. In a clinical and laboratory study, 153 women with androgenetic alopecia (AGA) and 32 control women were examined. In AGA patients telogen hair and vellus hair (miniaturization, D < 30 μm) significantly differed in frontal and parietal hair comparison with occipital area (20 ± 0.9% vs. 12 ± 0.5% and 33 ± 0.9% vs. 12 ± 0.6% respectively). In the AGA group levels of androstenedione and dihydrotestosterone were higher than in the control group. Hair elemental content, analyzed by ICP-MS, demonstrated a lowered Cu and Zn content in the frontal area in comparison to the occipital area. It is important to note, that the AGA patients with elevated levels of androstenedione and dihydrotestosterone presented an increased Cu content and decreased Mn, Se, Zn contents in the occipital area of scalp. The occipital level of Cu positively correlated with the concentration of free testosterone in the serum. A negative correlation between the Zn content in the occipital area and the dehydroepiandrosterone level in the blood was found. Unfortunately, a routine treatment course of AGA patients, including topical inhibitor of 5-alpha-reductase and minoxidil, had no effect on the Cu hair content in occipital and frontal areas. However, there were positive changes in the morphological structure and other trace element contents. These data led us to hypothesize a key role of Cu metabolism disturbances in the AGA onset, development of AGA, and potential pharmaceutical targets for the treatment of AGA. |
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