No altered blood pressure and serum markers of oxidative stress after a long time dietary fish oil in the genetically 9 month-old type-2 diabetes Zucker rat |
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| Institution: | 1. EA 2160 Mer Molécules Santé, PRES UNAM, Université du Maine, IUT de Laval, Département Génie Biologique, 52 rue des Drs Calmette et Guérin, BP 2045, 53020 Laval Cedex 9, France;2. Porsolt and Partners Pharmacology, 92100 Boulogne-Billancourt, France;1. Division of Plant Physiology and Biochemistry, Indian Institute of Horticultural Research, Hessaraghatta Lake Post, Bengaluru 560089, Karnataka, India;2. Division of Vegetable Crops, Indian Institute of Horticultural Research, Hessaraghatta Lake Post, Bengaluru 560089, Karnataka, India;1. Department of Pharmacology, Goethe-University of Frankfurt, D-60438 Frankfurt, Germany;2. Experimental Neurosurgery, Center for Neurology and Neurosurgery, Goethe-University Hospital, Neuroscience Center, D-60590 Frankfurt, Germany;3. LSU Neuroscience Center And Department of Ophthalmology, Louisiana State University, Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA;1. Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190, China;2. State Key Laboratory of High-temperature Gas Dynamics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;4. University of Science and Technology of China, Hefei 230026, China;1. College of Food Science & Technology, Engineering Research Center of Chestnut Industry Technology of Ministry of Education, Hebei Key Laboratory of Active Components and Functions in Natural Products, Hebei Normal University of Science and Technology, Qinhuangdao, Hebei 066004, China;2. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang 310058, China |
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| Abstract: | In this study, we investigated the effect of a high n-3 fatty acid diet (eicosapentaenoic and docosahexaenoic acids) in Zucker obese and lean rats on blood pressure in association with physiological parameters, serum biochemistry and oxidative stress analysis.After 150 days of treatment, dietary fish oil supplementation in Zucker obese rats (9 months of age) reduces bodyweight gain and serum triglyceridemia and nitrite levels, increases serum glucose and angiotensin converting enzyme activity, but does not alter blood pressure, cholesterol levels and serum markers of oxidative stress (malondialdehyde, glutathione), compared to the Zucker rats fed control diet.According to these results, we can consider that after 150 days of treatment, fish oil is not enough to regulate parameters involved in the metabolic syndrome, such as cholesterolemia and blood pressure, in a 9 month-old genetically type-2 diabetes rat. |
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