Time-course of malaoxon-induced alterations in brain regional inositol-1-phosphate levels in convulsing and nonconvulsing rats |
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Authors: | Maija-Riitta Hirvonen Hannu Komulainen Leo Paljärvi Kai Savolainen |
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Institution: | (1) Department of Industrial Hygiene, University of Kuopio, P.O. Box 6, SF-70201 Kuopio, Finland;(2) Present address: Department of Environmental Hygiene and Toxicology, National Public Health Institute, P.O. Box 95, SF-70701 Kuopio, Finland;(3) Department of Pathology, University Central Hospital of Kuopio, P.O.B. 6, SF-70211 Kuopio, Finland |
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Abstract: | The potential of a single dose of malaoxon (26.2 or 39.2 mg/kg i.p.) to produce convulsions and to increase cerebral levels of inositol-1-phosphate (Ins1P), an intermediate in phosphoinositide (PI) cycle, was followed for 1, 4, or 72 hr. The lower dose of malaoxon did not produce convulsions whereas the higher dose induced convulsions in 60% of the exposed rats. Malaoxon caused a dosedependent, at most 2-fold, increase in brain regional Ins1P levels in nonconvulsing rats as compared to controls. At the higher dose of malaoxon, in convulsing rats, the Ins1P-levels increased 4-fold above the control Ins1P-levels. In nonconvulsing rats, the Ins1P-levels reached their maximum 1–4 hr after the administration of malaoxon, whereas in convulsing rats the levels increased for 72 hr. The results suggest that PI-signalling is associated with convulsions produced by malaoxon. |
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Keywords: | Malaoxon convulsions brain inositol-1-phosphate |
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