Tetrahydrobiopterin administration to rhesus macaques |
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| Authors: | L. Miller T. Insel M. Scheinin J. Aloi D. L. Murphy M. Linnoila Dr. W. Lovenberg |
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| Affiliation: | (1) Section on Biochemical Pharmacology, NHLBI, 21205 Bethesda, Maryland;(2) Clinical Neuropharmacology Branch, NIMH, 21205 Bethesda, Maryland;(3) DICBR, NIAAA, National Institutes of Health NHLBI, 21205 Bethesda, Maryland;(4) Department of Pharmacology, University of Turku, Turku, Finland;(5) Merrell Dow Research Institute, 2110 E. Galbraith Road, 45215 Cincinnati, OH |
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| Abstract: | Tetrahydrobiopterin, the hydroxylase cofactor (BH4) was administered (i.v. 20 mg/kg) to Rhesus monkeys. Within 90 min of its administration CSF cofactor levels increased significantly above baseline levels. Peak CSF levels were attained at 90–180 min time period following cofactor injection and returned to baseline gradually over the next 15 hrs. The increased brain cofactor levels had no apparent effect on synthesis of dopamine, norepinephrine or serotonin as evidenced by a lack of change in the levels of the metabolites homovalillic acid, 3-methoxy-4-hydroxyphenyleneglycol, and 5-hydroxyindoleacetic acid. The present resultsAbbreviations BH4 tetrahydrobiopterin - CSF cerebrospinal fluid - 5-HIAA 5-hydroxyindoleacetic acid - HAV homovanillic acid - MHPG 3-methoxy-4-hydroxyphenyleneglycolSupported by Dystonia Medical Research Foundation, 9615 Brighton Way, Suite 416, Beverly Hills, California 90210 |
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