Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidis |
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Authors: | Francois Patrice Tu Quoc Patrick H Bisognano Carmelo Kelley William L Lew Daniel P Schrenzel Jacques Cramton Sarah E Götz Friedrich Vaudaux Pierre |
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Institution: | Division of Infectious Diseases, University Hospitals of Geneva, 1211 Geneva 14, Switzerland. patrice.francois@hcuge.ch |
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Abstract: | The contribution of in vivo biofilm-forming potential of Staphylococcus aureus and Staphylococcus epidermidis was studied in an experimental model of foreign body infections. Increasing inocula (from 10(2) to 10(7) organisms) of ica-positive strains of S. aureus and S. epidermidis and their ica-negative isogenic mutants (the ica locus codes for a major polysaccharide component of biofilm) were injected into subcutaneously implanted tissue cages in guinea pigs. Surprisingly, bacterial counts and time-course of tissue cage infection by ica-positive strains of S. aureus or S. epidermidis were equivalent to those of their respective ica-negative mutants, in the locally infected fluids and on tissue-cage-inserted plastic coverslips. |
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Keywords: | Foreign body infection Staphylococcus aureus Staphylococcus epidermidis Biofilm ica gene |
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