| Abstract: | PRCC‐TFE3 translocation renal cell carcinomas (tRCC) is a common subtype of TFE3 tRCCs in which TFE3 fusions are indicated as oncogenes to promote tumor development. PRCC‐TFE3 fusions are often accumulated in the nucleus and related to poorer outcomes and higher stages (III/IV). In this study, we found that PRCC‐TFE3 could positively regulate expression of both dynamin‐related protein 1 (Drp1) and fission protein 1, and alter distribution of mitochondria, which could promote cell migration and invasion independent of matrix metalloproteinase‐2 (MMP‐2) and MMP‐9. Together, our findings showed a new mechanism for PRCC‐TFE3 tRCC cell migration and invasion by alteration of mitochondrial dynamics. Thus, targeting dysregulated Drp1‐dependent mitochondrial fission may provide a novel strategy for suppressing the progression of PRCC‐TFE3 tRCC. |
