The amino terminal sequences of acid proteases-human pepsin and gastricsin and the protease of Rhizopus chinensis. |
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Authors: | P Sepulveda K W Jackson J Tang |
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Institution: | 1. Laboratory of Protein Studies, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA;2. Department of Biochemistry and Molecular Biology University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA |
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Abstract: | The amino acid sequences near the amino termini of human pepsin (34 residues) and gastricsin (24 residues) and the acid protease from (27 residues) have been determined using automated Edman degradation. From these results three additional observations were made. First, two structural variants have been observed for human gastricsin and for the protease. Both cases are apparently genetic in origin. Second, a stretch of sequence in the protease, residues 14 to 26, is highly homologous to the known sequence of porcine pepsin at the region of residues 11 to 23. Third, the sequences of the NH2-terminal region of human pepsin and gastrisin are homologous. |
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