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Decreased behavioral effects of daily intracerebroventricular bombesin |
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| Authors: | R. L. Corwin E. S. Corp J. Gibbs G. P. Smith |
| Affiliation: | a Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605, USA b E. W. Bourne Behavioral Research Laboratory, The New York Hospital-Cornell Medical Center, White Plains, NY 10605, USA |
| Abstract: | Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses. |
| Keywords: | Tolerance Grooming Ingestion Central effects of peptides Central effects of bombesin Food intake Feeding behavior |
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