Effect of Hypothalamic Proline-Rich-Polypeptide on Voltage-Gated Ca2+ Currents in Retinal Ganglion Cells |
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Authors: | Abram Akopian Armen Galoyan |
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Institution: | (1) Department of Ophthalmology, New York University School of Medicine, New York, New York;(2) Buniatian Institute of Biochemistry NAS RA, Yerevan, Armenia |
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Abstract: | Neurotrophins are molecules that regulate neuronal survival, nervous system plasticity, and many other physiological functions of neuronal and glial cells. Here we studied the physiological action of a novel neurosecretory polypeptide proline-rich polypeptide (PRP), isolated from bovine neurohypophysis neurosecretory granules, on voltage-gated Ca currents and spike firing activity of retinal ganglion cells. PRP reversibly increased high voltage–activated L-type Ca current, but was without effect on low voltage–activated T-type current. PRP also increased the spike after hyperpolarization and reduced the frequency of spike firing, most likely by affecting a Ca-dependent potassium current. |
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Keywords: | Neurotrophins retina Ca channel patch clamp spike |
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