Concise synthesis of a heptasaccharide antigen found in the cell-wall lipopolysaccharide of Mycobacterium gordonae strain 990 |
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Authors: | Rajib Panchadhayee Anup Kumar Misra |
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Affiliation: | (1) Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow, 226 001, India |
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Abstract: | A straight forward synthesis of a heptasaccharide part of the cell-wall lipopolysaccharide of Mycobacterium gordonae strain 990, known to have antigenicity, has been achieved in excellent yield. Judicious choice of protecting groups in the intermediates played a significant role throughout the synthesis. Most of the intermediate steps furnished satisfactory yield. Figure A concise synthesis of an antigenic heptasaccharide motif of the cell-wall glycolipid of Mycobacterium gordonae strain 990 in its preserved natural structure is presented using a general glycosylation condition and judicious protecting group manipulation C.D.R.I. communication number 7377. |
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Keywords: | Oligosaccharides Glycosylations Antigens Vaccines Mycobacterium gordonae 990 |
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