气味线索对小鼠形成吗啡依赖及渴求的影响

利用条件化位置偏好模型研究气味线索对吗啡依赖及渴求的影响,其结果发现,单一嗅觉条件刺激使小鼠建立条件化位置偏好,形成吗啡依赖。当改变外界环境,动物进入完全新异的环境后依然寻求与吗啡相关的气味线索,说明吗啡相关气味条件线索诱发了小鼠对吗啡的渴求。多巴胺D1或D2受体拮抗剂能阻断小鼠对气味线索的寻求。该结果表明嗅觉系统在药物成瘾过程中具有一定作用。

Effects of odor cue on morphine-induced dependence and craving in mice

The olfactory system may play a pivotal role in drug addiction. To clarify the issues, we investigated the morphine dependence and psychological craving in morphine addicted mice using the conditioned place preference (CPP) paradigm by taking an only odor cue as the conditioned stimulus (CS). The results showed that by pairing morphine with odor, the CPP could be induced in mice. When the morphine addicted mice were exposed to a novel environment during morphine withdrawal, they spent significantly longer time in the chamber with morphine-paired odor than in the control chamber. The effects of odor cue on the morphine CPP were blocked by the administration of dopamine D1 or D2 antagonists. The studies indicated that olfactory system plays an important role in drug addiction.