Exposure of Candida to p-anisaldehyde inhibits its growth and ergosterol biosynthesis |
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Authors: | Shreaz Sheikh Bhatia Rimple Khan Neelofar Muralidhar Sumathi Basir Seemi F Manzoor Nikhat Khan Luqman Ahmad |
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Institution: | Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India. |
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Abstract: | p-Anisaldehyde (4-methoxybenzaldehyde), an extract from Pimpinella anisum seeds, is a very common digestive herb of north India. Antifungal activity of p-anisaldehyde was investigated on 10 fluconazole-resistant and 5 fluconazole-sensitive Candida strains. Minimum inhibitory concentrations (MIC(90)) ranged from 250 μg/ml to 600 μg/ml for both sensitive and resistant strains. Ergosterol content was drastically reduced by p-anisaldehyde-62% in sensitive and 66% in resistant strains-but did not corelate well with MIC(90) values. It appears that p-anisaldehyde exerts its antifungal effect by decreasing NADPH routed through up-regulation of putative aryl-alcohol dehydrogenases. Cellular toxicity of p-anisaldehyde against H9c2 rat cardiac myoblasts was less than 20% at the highest MIC value. These findings encourage further development of p-anisaldehyde. |
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