Magnetic resonance imaging of self-assembled biomaterial scaffolds |
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Authors: | Bull Steve R Guler Mustafa O Bras Rafael E Venkatasubramanian Palamadai N Stupp Samuel I Meade Thomas J |
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Institution: | Department of Chemistry, Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60208, USA. |
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Abstract: | Current interest in biomaterials for tissue engineering and drug delivery applications have spurred research into self-assembling peptide amphiphiles (PAs). Nanofiber networks formed from self-assembling PAs can be used as biomaterial scaffolds with the advantage of specificity by the incorporation of peptide-epitopes. Imaging the materials noninvasively will give information as to their fate in vivo. We report here the synthesis and in vitro MR images of self-assembling peptide amphiphile contrast agents (PACAs) that form nanofibers. At 400 MHz using a 0.1 mM Gd(III) conjugate of the PA we observed a T(1) three times that of a control gel. The PA derivative was doped into various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as imaged by MRI. |
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