Sequence of amino acids comprising the single intra-chain disulfide loop in the alpha-chain of human fibrinogen.

Amino acid sequence studies have revealed that the largest cyanogen bromide fragment from the α-chain of human fibrinogen contains two cysteine residues which are situated thirty residues apart and near the carboxy-terminal end of that fragment. In contrast to a recent report, no other cysteines exist in this region of the α-chain. The sequence has been compared to disulfide loops in the β- and γ-chains and some very marginal homology suggested.