Triterpenoidal alkaloids from Buxus hyrcana and their enzyme inhibitory,anti-fungal and anti-leishmanial activities |
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| Authors: | Athar Ata Chad D. Iverson Kosmulalage S. Kalhari Sarfraz Akhter Jordan Betteridge Mohammad Hadi Meshkatalsadat Ilkay Orhan Bilge Sener |
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| Affiliation: | 1. Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, MB, Canada R3B 2E9;2. Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada R3N 2T2;3. Department of Chemistry, Faculty of Science, University of Lorestan, Koramabad, Iran;4. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey |
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| Abstract: | From the aerial parts of Buxus hyrcana, three triterpenoidal alkaloids, 17-oxo-3-benzoylbuxadine (1), buxhyrcamine (2), and 31-demethylcyclobuxoviridine (3), along with 16 known compounds, cyclobuxoviridine (4), Nb-dimethylcyclobuxoviricine (5), E-buxenone (6), Z-buxenone (7), moenjodaramine (8), homomoenjodarmine (9), buxamine A (10), buxamine B (11), 31-hydroxybuxamine B (12), N20-formylbuxaminol E (13), papillozine C (14), buxmicrophylline F (15), buxrugulosamine (16), cyclobuxophylline O (17), spirofornabuxine (18) and arbora-1,9(11)-dien-3-one (19) were isolated. Their structures were elucidated by using NMR spectroscopic methods. All of the compounds exhibited moderate to weak acetylcholinesterase, butyrylcholinesterase and glutathione S-transferase inhibitory activities. Compounds 1–19 also exhibited modest anti-fungal activities against Candida albicans. Compounds 1, 2, 8, 9 and 18 also exhibited weak anti-leishmanial activity. |
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