Bioactive jatrophane diterpenes from Euphorbia guyoniana |
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| Authors: | Mohamed-Elamir F Hegazy Abou El-Hamd H Mohamed Nobuwa Aoki Toshitaka Ikeuchi Emi Ohta Shinji Ohta |
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| Institution: | 1. Chemistry of Medicinal Plants Department, National Research Center, Dokki, Cairo, Egypt;2. Department of Chemistry, Aswan-Faculty of Science, South Valley University, Aswan, Egypt;3. Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga 526-0829, Japan;4. Pharmaceutical Laboratory, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Cairo, Egypt |
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| Abstract: | Chromatographic investigation of the methylenechloride/methanol extract of the aerial parts of Euphorbia guyoniana afforded two jatrophane diterpenes, designated guyonianins E and F, in addition to a known jatrophane diterpene. The structures of the compounds were determined by comprehensive NMR analyses, including DEPT, COSY, HMQC, HMBC, NOESY and HRMS. These compounds exhibited cytotoxicity against human embryonic kidney 293 (HEK293) cells with IC50 values of 35–100 μM. |
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